Environmental toxicants exposure can alter both transcriptome and epigenome in mammals. These multi-level molecular changes have been associated with many environmental exposure-induced diseases across the lifespan, such as cardiovascular disease, cancer, and other neurological disorders. Rooting from the TaRGET II Consortium (Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription), the largest data cohort of molecular changes under the influence of different environmental toxicants exposure so far, we constructed ToxiTaRGET, a platform for integrative visualization of 2,758 omics data. ToxiTaRGET contains the comprehensive molecular signatures, including gene expression and epigenetic modification in responding to the exposure of arsenic (As), lead (Pb), bisphenol A (BPA), tributyltin (TBT), the phthalate di-2-Ethylhexyl phthalate (DEHP), the dioxin tetrachlorodibenzo-p-dioxin (TCDD), or air pollution in the form of particulate matter <2.5μm (PM2.5) in mice embryonic and early postnatal development stage. ToxiTaRGET allows users to explore multi-omics TaRGET data across different tissues, exposures, aging stages, and sex in a customized configuration. Using a text-mining approach, we identified thousands of molecular changes responding to various environmental exposures from publicly reported PubMed Central literates. All these known molecular changes were also indexed and searchable in ToxiTaRGET to allow users better integrate TaRGET data with previous knowledge in an open-source fashion.