Function: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages (PubMed:19131592, PubMed:19158675, PubMed:19158676, PubMed:20351692, PubMed:20351693, PubMed:20417169, PubMed:20457908, PubMed:21902795, PubMed:23567559). Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precursor and processing of interleukin-1 beta and interleukin-18 (PubMed:19131592, PubMed:19158675, PubMed:19158676, PubMed:20351692, PubMed:20351693, PubMed:20417169, PubMed:20457908, PubMed:21902795, PubMed:23567559). Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner (PubMed:19131592, PubMed:19158675, PubMed:20351692, PubMed:23567559). Also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (PubMed:34471287). Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (PubMed:22555457). {ECO:0000269|PubMed:19131592, ECO:0000269|PubMed:19158675, ECO:0000269|PubMed:19158676, ECO:0000269|PubMed:20351692, ECO:0000269|PubMed:20351693, ECO:0000269|PubMed:20417169, ECO:0000269|PubMed:20457908, ECO:0000269|PubMed:21902795, ECO:0000269|PubMed:22555457, ECO:0000269|PubMed:23567559, ECO:0000269|PubMed:34471287}. Subcellular Location: Nucleus {ECO:0000250|UniProtKB:O14862}. Cytoplasm {ECO:0000269|PubMed:22555457}.
Expression of "Aim2"gene in different tissues
Tools:
Viewing a 62.0 Kb region in 920px, 1 pixel spans 67 bp
