ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Bpgm2,3-bisphosphoglycerate mutaseENSMUSG00000038871protein-codingPMGE_MOUSEAlphaFold
Function: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. {ECO:0000250|UniProtKB:P07738}.
Subcellular Location:

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Bpgm"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD1020304050
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD1020304050
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT2k4k6k8k10k12k
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT2k4k6k8k10k12k
3 Weeks20 Weeks40 WeeksBloodMale
CtrlPM2.5(CHI)406080100120
3 Weeks20 WeeksCPMFemale
CtrlPM2.5(CHI)406080100120
3 Weeks20 WeeksLungMale
CtrlPM2.5(CHI)0102030
Female
0102030
HeartMale
BPA10mgBPA10ugCtrl40506070
Female
BPA10mgBPA10ugCtrl40506070
BrainMale




Tools:
Viewing a 135.9 Kb region in 920px, 1 pixel spans 148 bp
  • Sample

refGene

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gencodeM19Basic

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Ruler

chr6
qB134320K34330K34340K34350K34360K34370K34380K34390K34400K34410K34420K34430K34440K34450K34460K34470K34480K34490K34500K34510K34520K34530K34540K34550K34560K34570K34580K34590K34600K34610K34620K34630K34640K34650K34660K34670K34680K34690K34700K34710K

3 Weeks Female Liver (Ctrl)

1.00.0
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3 Weeks Male Liver (Ctrl)

1.00.0
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20 Weeks Female Blood (Ctrl)

1.00.0
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20 Weeks Male Blood (Ctrl)

1.00.0
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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Bpgm" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr6:34448054-34448288-28185YESIntergenic
2chr6:34449978-34450222-26256YESIntergenic
3chr6:34453283-34453676-22876YESIntergenic
4chr6:34455495-34455735-20741NOIntergenic
5chr6:34470349-34470571-5896NOIntergenic
6chr6:34471786-34472007-4459YESIntergenic
7chr6:34475845-34476746-60YESpromoter-TSS (NM_007563)
8chr6:34479618-344798483377NOintron (NM_007563, intron 1 of 2)
9chr6:34481406-344816855190NOintron (NM_007563, intron 1 of 2)
10chr6:34486055-344863909867NOintron (NM_007563, intron 1 of 2)
11chr6:34490475-3449069814231NOintron (NM_007563, intron 2 of 2)
12chr6:34493376-3449390917287NOintron (NM_007563, intron 2 of 2)
13chr6:34495034-3449567919001YESintron (NM_007563, intron 2 of 2)
14chr6:34499376-3449964523155NOintron (NM_007563, intron 2 of 2)
15chr6:34502460-3450274026244NOintron (NM_007563, intron 2 of 2)
16chr6:34505987-3450634929812NOTTS (NM_007563)
17chr6:34511400-3451177335231NOIntergenic
18chr6:34514761-3451492138485NOIntergenic
19chr6:34515079-3451558838978NOIntergenic
20chr6:34527515-3452859151697NOIntergenic
21chr6:34532854-3453341056776YESIntergenic
22chr6:34542855-3454329966721NOIntergenic
23chr6:34549099-3454933272860NOIntergenic
24chr6:34567325-3456756191087NOIntergenic
25chr6:34579498-34579936103361YESIntergenic


Exposure induced DNA methylation change