ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Dedd2	death effector domain-containing DNA binding protein 2	ENSMUSG00000054499	protein-coding	DEDD2_MOUSE	AlphaFold

Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Subcellular Location: Nucleus, nucleolus {ECO:0000250}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli. {ECO:0000250}.

Expression of "Dedd2"gene in different tissues

OCR associated with "Dedd2" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr7:25219305-25220154	129	NO	intron (NM_207677, intron 1 of 4)
2	chr7:25218804-25219027	943	NO	exon (NM_207677, exon 2 of 5)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Dedd2"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Dedd2" gene

Exposure induced DNA methylation change