ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Fads2fatty acid desaturase 2ENSMUSG00000024665protein-codingFADS2_MOUSEAlphaFold
Function: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:9867867). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). {ECO:0000250|UniProtKB:B8R1K0, ECO:0000250|UniProtKB:Q9Z122, ECO:0000269|PubMed:9867867}.
Subcellular Location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.

Expression of "Fads2"gene in different tissues





OCR associated with "Fads2" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr19:10134728-10135038-33380YESIntergenic
2chr19:10126559-10127291-25422NOIntergenic
3chr19:10121998-10122716-20854NOIntergenic
4chr19:10116485-10116925-15202NOIntergenic
5chr19:10115798-10116276-14534NOIntergenic
6chr19:10113156-10113353-11752NOIntergenic
7chr19:10111638-10111905-10269YESIntergenic
8chr19:10108078-10108422-6747NOIntergenic
9chr19:10104311-10104611-2958NOIntergenic
10chr19:10102455-10102660-1055NOIntergenic
11chr19:10101329-10102266-295YESpromoter-TSS (NM_019699)
12chr19:10100764-10101071585YESintron (NM_019699, intron 1 of 11)
13chr19:10097925-100980933494NOintron (NM_019699, intron 1 of 11)
14chr19:10096983-100972024410NOintron (NM_019699, intron 1 of 11)
15chr19:10096359-100967734937NOintron (NM_019699, intron 1 of 11)
16chr19:10094813-100950286582YESintron (NM_019699, intron 1 of 11)
17chr19:10090661-1009094610699YESintron (NM_019699, intron 2 of 11)
18chr19:10089108-1008928712305YESintron (NM_019699, intron 2 of 11)
19chr19:10087066-1008745114244YESintron (NM_019699, intron 4 of 11)
20chr19:10085986-1008623915390YESintron (NM_019699, intron 4 of 11)
21chr19:10085478-1008573415897NOintron (NM_019699, intron 4 of 11)
22chr19:10082665-1008286818736NOintron (NM_019699, intron 4 of 11)
23chr19:10082167-1008246619186NOintron (NM_019699, intron 5 of 11)
24chr19:10078580-1007880222812NOintron (NM_019699, intron 5 of 11)
25chr19:10078148-1007837923239NOintron (NM_019699, intron 5 of 11)
26chr19:10076884-1007756724277YESintron (NM_019699, intron 5 of 11)
27chr19:10074618-1007482826780YESintron (NM_019699, intron 5 of 11)
28chr19:10071104-1007196729967NOintron (NM_019699, intron 5 of 11)


Exposure induced DNA methylation change