ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Fbp1fructose bisphosphatase 1ENSMUSG00000069805protein-codingF16P1_MOUSEAlphaFold
Function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:20719858}.
Subcellular Location:

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−1−0.500.51Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−1−0.500.51Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Fbp1"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD6008001000120014001600
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD6008001000120014001600
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT0123456
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT0123456
3 Weeks20 Weeks40 WeeksBloodMale





Tools:
Viewing a 48.9 Kb region in 920px, 1 pixel spans 53 bp
  • Sample

refGene

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gencodeM19Basic

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Ruler

chr13
qB362830K62840K62850K62860K62870K62880K62890K62900K62910K62920K62930K62940K62950K62960K62970K

3 Weeks Female Liver (Ctrl)

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3 Weeks Male Liver (Ctrl)

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20 Weeks Female Blood (Ctrl)

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20 Weeks Male Blood (Ctrl)

1.00.0
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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Fbp1" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr13:62919696-62920206-31669YESIntergenic
2chr13:62916688-62917090-28607NOIntergenic
3chr13:62909830-62910048-21657YESIntergenic
4chr13:62909276-62909589-21151YESIntergenic
5chr13:62907896-62908644-19988NOIntergenic
6chr13:62897921-62898477-9917NOIntergenic
7chr13:62893541-62893844-5411NOIntergenic
8chr13:62893158-62893326-4960NOIntergenic
9chr13:62889422-62889593-1226NOIntergenic
10chr13:62888977-62889253-833NOpromoter-TSS (NM_019395)
11chr13:62887875-6288865019YESpromoter-TSS (NM_019395)
12chr13:62884010-628842274163NOintron (NM_019395, intron 1 of 6)
13chr13:62883436-628838084660NOintron (NM_019395, intron 1 of 6)
14chr13:62882944-628831445238NOintron (NM_019395, intron 1 of 6)
15chr13:62881426-628816606739NOintron (NM_019395, intron 1 of 6)
16chr13:62880021-628805298007NOintron (NM_019395, intron 1 of 6)
17chr13:62878136-628784939967YESintron (NM_019395, intron 1 of 6)
18chr13:62877337-6287774510741NOintron (NM_019395, intron 1 of 6)
19chr13:62875761-6287597012416NOintron (NM_019395, intron 1 of 6)
20chr13:62875350-6287558012817YESintron (NM_019395, intron 1 of 6)



Exposure induced DNA methylation change