ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Grb7growth factor receptor bound protein 7ENSMUSG00000019312protein-codingGRB7_MOUSEAlphaFold
Function: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration (By similarity). Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. {ECO:0000250, ECO:0000269|PubMed:17318180, ECO:0000269|PubMed:18273060}.
Subcellular Location: Cytoplasm {ECO:0000269|PubMed:18273060}. Cell projection {ECO:0000250|UniProtKB:Q14451}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q14451}. Cell membrane {ECO:0000250|UniProtKB:Q14451}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14451}; Cytoplasmic side {ECO:0000250|UniProtKB:Q14451}. Cytoplasmic granule {ECO:0000269|PubMed:18273060}. Note=Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions. {ECO:0000269|PubMed:18273060}.

Expression of "Grb7"gene in different tissues





OCR associated with "Grb7" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr11:98445810-98446029-914YESpromoter-TSS (NM_010346)
2chr11:98446354-98447104-105NOpromoter-TSS (NM_010346)
3chr11:98447304-98447468552NOintron (NM_010346, intron 1 of 14)
4chr11:98448142-984488001637NOintron (NM_010346, intron 1 of 14)
5chr11:98450113-984505793512NOintron (NM_010346, intron 1 of 14)
6chr11:98455626-984559808969NOTTS (NM_010346)
7chr11:98457037-9845812110745NOIntergenic
8chr11:98459220-9845966512609NOIntergenic
9chr11:98463944-9846430217289NOTTS (NM_011771)
10chr11:98464580-9846485117882YESTTS (NM_011771)
11chr11:98469861-9847005023122NOintron (NM_011771, intron 7 of 7)
12chr11:98470243-9847049923537NOintron (NM_011771, intron 7 of 7)
13chr11:98470764-9847111924108NOintron (NM_011771, intron 7 of 7)
14chr11:98472261-9847248625540YESintron (NM_011771, intron 7 of 7)
15chr11:98472681-9847293325973NOintron (NM_011771, intron 7 of 7)
16chr11:98477163-9847744030468NOintron (NM_011771, intron 6 of 7)
17chr11:98479529-9847991732889NOintron (NM_011771, intron 6 of 7)
18chr11:98481318-9848154434597NOintron (NM_011771, intron 6 of 7)
19chr11:98487576-9848805840983YESintron (NM_011771, intron 5 of 7)
20chr11:98491659-9849192244957YESintron (NM_011771, intron 3 of 7)
21chr11:98492948-9849341146346NOintron (NM_011771, intron 3 of 7)


Exposure induced DNA methylation change