ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Lgals1	lectin, galactose binding, soluble 1	ENSMUSG00000068220	protein-coding	LEG1_MOUSE	AlphaFold

Function: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000250|UniProtKB:P09382, ECO:0000269|PubMed:1986871}.
Subcellular Location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P09382}. Cytoplasm {ECO:0000250|UniProtKB:P09382}. Secreted {ECO:0000250|UniProtKB:P09382}. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P09382}.

Expression of "Lgals1"gene in different tissues

OCR associated with "Lgals1" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr15:78921978-78922286	-4593	NO	Intergenic
2	chr15:78923610-78923875	-2982	NO	Intergenic
3	chr15:78925222-78925487	-1370	YES	Intergenic
4	chr15:78925946-78926382	-561	NO	promoter-TSS (NM_008495)
5	chr15:78926603-78926801	-23	NO	promoter-TSS (NM_008495)
6	chr15:78927160-78927410	560	NO	intron (NM_008495, intron 1 of 3)
7	chr15:78928070-78928442	1531	YES	intron (NM_008495, intron 2 of 3)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Lgals1"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Lgals1" gene

Exposure induced DNA methylation change