ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Lrp5	low density lipoprotein receptor-related protein 5	ENSMUSG00000024913	protein-coding	LRP5_MOUSE	AlphaFold

Function: Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11956231). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (PubMed:15142971). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11956231). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (By similarity). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (By similarity). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (PubMed:11956231). {ECO:0000250|UniProtKB:O75197, ECO:0000269|PubMed:11956231, ECO:0000269|PubMed:15142971}.
Subcellular Location: Membrane {ECO:0000269|PubMed:12581525}; Single-pass type I membrane protein {ECO:0000269|PubMed:12581525}. Endoplasmic reticulum {ECO:0000269|PubMed:12581525}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250}.

Expression of "Lrp5"gene in different tissues

OCR associated with "Lrp5" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr19:3696052-3696230	-9577	NO	Intergenic
2	chr19:3695072-3695855	-8900	NO	Intergenic
3	chr19:3691347-3691576	-4898	NO	Intergenic
4	chr19:3687505-3688183	-1280	YES	Intergenic
5	chr19:3686447-3686928	-124	YES	promoter-TSS (NM_008513)
6	chr19:3685712-3686260	578	NO	intron (NM_008513, intron 1 of 22)
7	chr19:3681183-3681847	5049	YES	intron (NM_008513, intron 1 of 22)
8	chr19:3680798-3681013	5658	NO	intron (NM_008513, intron 1 of 22)
9	chr19:3679255-3679719	7077	NO	intron (NM_008513, intron 1 of 22)
10	chr19:3673975-3674968	12092	NO	intron (NM_008513, intron 1 of 22)
11	chr19:3672496-3672808	13912	YES	intron (NM_008513, intron 1 of 22)
12	chr19:3669102-3669406	17310	YES	intron (NM_008513, intron 1 of 22)
13	chr19:3668043-3668313	18386	YES	intron (NM_008513, intron 1 of 22)
14	chr19:3667126-3667539	19231	NO	intron (NM_008513, intron 1 of 22)
15	chr19:3666675-3666904	19774	NO	intron (NM_008513, intron 1 of 22)
16	chr19:3665430-3665839	20929	NO	intron (NM_008513, intron 1 of 22)
17	chr19:3659183-3659750	27097	NO	exon (NM_008513, exon 2 of 23)
18	chr19:3656112-3656469	30273	NO	intron (NM_008513, intron 2 of 22)
19	chr19:3655031-3655282	31407	YES	intron (NM_008513, intron 2 of 22)
20	chr19:3653978-3654519	32315	YES	intron (NM_008513, intron 2 of 22)
21	chr19:3650477-3650903	35874	YES	intron (NM_008513, intron 3 of 22)
22	chr19:3645419-3646211	40749	YES	intron (NM_008513, intron 5 of 22)
23	chr19:3643783-3644029	42658	NO	intron (NM_008513, intron 5 of 22)
24	chr19:3641972-3642187	44484	NO	intron (NM_008513, intron 5 of 22)
25	chr19:3638616-3639247	47632	YES	intron (NM_008513, intron 5 of 22)
26	chr19:3634971-3635456	51350	YES	intron (NM_008513, intron 5 of 22)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Lrp5"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Lrp5" gene

Exposure induced DNA methylation change