ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Lrrc59	leucine rich repeat containing 59	ENSMUSG00000020869	protein-coding	LRC59_MOUSE	AlphaFold

Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). {ECO:0000250}.
Subcellular Location: Microsome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. {ECO:0000250}.

Expression of "Lrrc59"gene in different tissues

OCR associated with "Lrrc59" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr11:94629343-94630034	-135	NO	promoter-TSS (NM_133807)
2	chr11:94630395-94631096	922	NO	intron (NM_133807, intron 1 of 6)
3	chr11:94633089-94633299	3370	YES	intron (NM_133807, intron 2 of 6)
4	chr11:94634508-94634753	4807	YES	exon (NM_133807, exon 3 of 7)
5	chr11:94636973-94637196	7261	YES	intron (NM_133807, intron 4 of 6)
6	chr11:94637443-94637922	7859	YES	intron (NM_133807, intron 4 of 6)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Lrrc59"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Lrrc59" gene

Exposure induced DNA methylation change