ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Lypla2	lysophospholipase 2	ENSMUSG00000028670	protein-coding	LYPA2_MOUSE	AlphaFold

Function: Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (By similarity). Deacylates GAP43 (By similarity). Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (PubMed:10064901). Hydrolyzes prostaglandin glycerol esters (PG-Gs) (PubMed:25301951). Hydrolyzes PG-Gs in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (By similarity). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity). {ECO:0000250|UniProtKB:O95372, ECO:0000269|PubMed:10064901}.
Subcellular Location: Cytoplasm {ECO:0000250|UniProtKB:O95372}.

Expression of "Lypla2"gene in different tissues

OCR associated with "Lypla2" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr4:135972044-135972968	88	NO	promoter-TSS (NM_011942)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Lypla2"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Lypla2" gene

Exposure induced DNA methylation change