ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Mapk4mitogen-activated protein kinase 4ENSMUSG00000024558protein-codingMK04_MOUSEAlphaFold
Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. {ECO:0000269|PubMed:16973613}.
Subcellular Location: Cytoplasm {ECO:0000269|PubMed:16973613}. Nucleus {ECO:0000269|PubMed:16973613}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5.

Expression of "Mapk4"gene in different tissues





OCR associated with "Mapk4" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr18:74126861-74127420-62192NOIntergenic
2chr18:74120669-74120911-55841YESIntergenic
3chr18:74118312-74118899-53657NOIntergenic
4chr18:74107041-74107805-42474YESIntergenic
5chr18:74106014-74106516-41316YESIntergenic
6chr18:74100918-74101176-36098YESIntergenic
7chr18:74095693-74096127-30961NOIntergenic
8chr18:74090334-74090819-25628YESIntergenic
9chr18:74089129-74089827-24529NOIntergenic
10chr18:74084548-74085116-19883NOIntergenic
11chr18:74064468-74065448-9YESpromoter-TSS (NM_172632)
12chr18:74063816-74064297892NOintron (NM_172632, intron 1 of 5)


Exposure induced DNA methylation change