ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Mbd4	methyl-CpG binding domain protein 4	ENSMUSG00000030322	protein-coding	A0A0R4J0A8_MOUSE	AlphaFold

Function: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000256|PIRNR:PIRNR038005}.
Subcellular Location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR038005}.

Expression of "Mbd4"gene in different tissues

OCR associated with "Mbd4" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr6:115848833-115849304	4272	YES	exon (NM_010774, exon 3 of 8)
2	chr6:115848234-115848490	4979	NO	intron (NM_010774, intron 3 of 7)
3	chr6:115846949-115847353	6190	YES	intron (NM_010774, intron 3 of 7)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Mbd4"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Mbd4" gene

Exposure induced DNA methylation change