ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Med16	mediator complex subunit 16	ENSMUSG00000013833	protein-coding	E9QP84_MOUSE	AlphaFold

Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|RuleBase:RU364149}.
Subcellular Location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU364149}.

Expression of "Med16"gene in different tissues

OCR associated with "Med16" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr10:79908244-79909486	73	NO	promoter-TSS (NM_001163276)
2	chr10:79900765-79901423	7844	YES	intron (NM_198107, intron 6 of 14)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Med16"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Med16" gene

Exposure induced DNA methylation change