Gene information

Function: Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (By similarity). {ECO:0000250|UniProtKB:Q99550, ECO:0000269|PubMed:30375385}.
Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q99550}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q99550}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99550}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30375385}. Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole (By similarity). Recruited by KIF24 to the distal end of mother centriole where it forms a ring-like structure (By similarity). {ECO:0000250|UniProtKB:Q99550}.

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Exposure induced DNA methylation change