ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Mreg	melanoregulin	ENSMUSG00000039395	protein-coding	MREG_MOUSE	AlphaFold

Function: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery (PubMed:22940130, PubMed:22275436, PubMed:30174147). Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes (PubMed:15550542, PubMed:3410303, PubMed:22753477). Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center (PubMed:22940130, PubMed:22275436). Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell (PubMed:19240024, PubMed:30174147). Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport (PubMed:30174147). Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (PubMed:19240024). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed:19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye (PubMed:19240024). May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (Probable). {ECO:0000269|PubMed:15550542, ECO:0000269|PubMed:19240024, ECO:0000269|PubMed:22275436, ECO:0000269|PubMed:22753477, ECO:0000269|PubMed:22940130, ECO:0000269|PubMed:30174147, ECO:0000269|PubMed:3410303, ECO:0000305|PubMed:17260955}.
Subcellular Location: Apical cell membrane {ECO:0000269|PubMed:17260955}; Peripheral membrane protein {ECO:0000269|PubMed:17260955}. Melanosome membrane {ECO:0000269|PubMed:22275436, ECO:0000269|PubMed:22940130}; Lipid-anchor {ECO:0000269|PubMed:22940130}. Lysosome membrane {ECO:0000269|PubMed:22940130, ECO:0000269|PubMed:30174147}; Lipid-anchor {ECO:0000269|PubMed:22940130}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:19240024}. Note=Localizes to the inner segment and basal outer segment of rods in the retina. {ECO:0000269|PubMed:17260955}.

Expression of "Mreg"gene in different tissues

Tools:

Viewing a 125.1 Kb region in 920px, 1 pixel spans 136 bp

Sample

refGene

gencodeM19Basic

Ruler

chr1

3 Weeks Female Liver (Ctrl)

3 Weeks Male Liver (Ctrl)

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20 Weeks Male Liver (Ctrl)

DAR Position

OCR Position

OCR associated with "Mreg" gene

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OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr1:72243635-72244615	-31818	NO	Intergenic
2	chr1:72237480-72237747	-25307	NO	Intergenic
3	chr1:72236358-72237282	-24513	NO	Intergenic
4	chr1:72233754-72234030	-21585	YES	Intergenic
5	chr1:72231514-72231710	-19305	YES	Intergenic
6	chr1:72231026-72231226	-18819	NO	Intergenic
7	chr1:72225699-72226698	-13892	NO	Intergenic
8	chr1:72221835-72222053	-9637	NO	Intergenic
9	chr1:72220064-72220303	-7877	YES	Intergenic
10	chr1:72219147-72219456	-6995	YES	Intergenic
11	chr1:72214518-72214885	-2395	YES	Intergenic
12	chr1:72211775-72212463	188	YES	5' UTR (NM_001005423, exon 1 of 5)
13	chr1:72210632-72211243	1369	NO	intron (NM_001005423, intron 1 of 4)
14	chr1:72198729-72199347	13269	YES	intron (NM_001005423, intron 1 of 4)
15	chr1:72182956-72183546	29056	NO	intron (NM_001005423, intron 2 of 4)
16	chr1:72179763-72180343	32254	NO	intron (NM_001005423, intron 2 of 4)
17	chr1:72177465-72177706	34721	YES	intron (NM_001005423, intron 2 of 4)
18	chr1:72176315-72176550	35874	NO	intron (NM_001005423, intron 2 of 4)
19	chr1:72173185-72173878	38775	NO	intron (NM_001005423, intron 2 of 4)
20	chr1:72171019-72171294	41150	NO	intron (NM_001005423, intron 2 of 4)
21	chr1:72141937-72142182	70247	YES	Intergenic
22	chr1:72134611-72134857	77573	NO	Intergenic
23	chr1:72123546-72123969	88549	YES	Intergenic

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Mreg"gene in different tissues

Exposure induced chromatin accessibility change

Current terms

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OCR associated with "Mreg" gene

Exposure induced DNA methylation change