ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Neurl3neuralized E3 ubiquitin protein ligase 3ENSMUSG00000047180protein-codingNEUL3_MOUSEAlphaFold
Function: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:15936721, PubMed:35792897). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). {ECO:0000269|PubMed:15936721, ECO:0000269|PubMed:35792897}.
Subcellular Location: Cytoplasm {ECO:0000250|UniProtKB:Q96EH8}.

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Neurl3"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD5101520
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD5101520
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT50100150200250300
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT50100150200250300
3 Weeks20 Weeks40 WeeksBloodMale
CtrlPM2.5(CHI)2030405060
3 Weeks20 WeeksCPMFemale
CtrlPM2.5(CHI)2030405060
3 Weeks20 WeeksLungMale
CtrlPM2.5(CHI)0510
Female
0510
HeartMale
BPA10mgBPA10ugCtrl00.511.5
Female
BPA10mgBPA10ugCtrl00.511.5
BrainMale




Tools:
Viewing a 27.7 Kb region in 920px, 1 pixel spans 30 bp
  • Sample

refGene

Uggt1Neurl3Arid5aArid5aArid5aArid5aArid5aArid5a

gencodeM19Basic

Uggt1Neurl3Neurl3Arid5aArid5aArid5aArid5aArid5a

Ruler

chr1
qB36230K36240K36250K36260K36270K36280K36290K36300K36310K

3 Weeks Female Liver (Ctrl)

1.00.0
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3 Weeks Male Liver (Ctrl)

1.00.0
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20 Weeks Female Blood (Ctrl)

1.00.0
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20 Weeks Male Blood (Ctrl)

1.00.0
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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Neurl3" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr1:36281836-36282455-8721NOIntergenic
2chr1:36279243-36279516-5955NOIntergenic
3chr1:36277347-36277581-4039NOIntergenic
4chr1:36274416-36274628-1097NOIntergenic
5chr1:36273126-3627368519YESpromoter-TSS (NM_153408)
6chr1:36272439-36272879766NOintron (NM_153408, intron 1 of 3)
7chr1:36271591-362719091675NOintron (NM_153408, intron 1 of 3)
8chr1:36270642-362710032602YESintron (NM_153408, intron 1 of 3)
9chr1:36263973-362645959141YESTTS (NM_153408)
10chr1:36262089-3626248511138YESIntergenic
11chr1:36258804-3625913914453NOIntergenic


Exposure induced DNA methylation change