ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Nr0b2nuclear receptor subfamily 0, group B, member 2ENSMUSG00000037583protein-codingNR0B2_MOUSEAlphaFold
Function: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:8650544). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:8650544). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (PubMed:25212631). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (PubMed:30555544). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (PubMed:30555544). {ECO:0000250|UniProtKB:Q15466, ECO:0000269|PubMed:25212631, ECO:0000269|PubMed:30555544, ECO:0000269|PubMed:8650544}.
Subcellular Location: Cytoplasm {ECO:0000250|UniProtKB:Q15466}. Nucleus {ECO:0000250|UniProtKB:Q15466}. Note=Colocalizes with NEUROD1 in the nucleus. {ECO:0000250|UniProtKB:Q15466}.

Expression of "Nr0b2"gene in different tissues





OCR associated with "Nr0b2" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr4:133552052-133552391-1154NOIntergenic
2chr4:133552707-133553610-217NOpromoter-TSS (NM_011850)
3chr4:133557150-1335578554127NOTTS (NM_011850)
4chr4:133559922-1335601706670NOIntergenic
5chr4:133561762-1335619398475NOIntergenic
6chr4:133563029-1335636659971NOIntergenic


Exposure induced DNA methylation change