ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Nthl1	nth (endonuclease III)-like 1 (E.coli)	ENSMUSG00000041429	protein-coding	NTH_MOUSE	AlphaFold

Function: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:9743625}.
Subcellular Location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03183}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:12531031}.

Expression of "Nthl1"gene in different tissues

Tools:

Viewing a 10.4 Kb region in 920px, 1 pixel spans 11 bp

Sample

refGene

gencodeM19Basic

Ruler

chr17

3 Weeks Female Liver (Ctrl)

3 Weeks Male Liver (Ctrl)

20 Weeks Female Blood (Ctrl)

20 Weeks Male Blood (Ctrl)

20 Weeks Female Brain (Ctrl)

20 Weeks Male Brain (Ctrl)

20 Weeks Female Liver (Ctrl)

20 Weeks Male Liver (Ctrl)

DAR Position

OCR Position

OCR associated with "Nthl1" gene

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OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr17:24632342-24633284	131	NO	promoter-TSS (NM_011647)
2	chr17:24635072-24635342	2525	YES	intron (NM_008743, intron 3 of 5)
3	chr17:24638465-24638730	5916	YES	TTS (NM_023449)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Nthl1"gene in different tissues

Exposure induced chromatin accessibility change

Current terms

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OCR associated with "Nthl1" gene

Exposure induced DNA methylation change