ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Phospho1phosphatase, orphan 1ENSMUSG00000050860protein-codingPHOP1_MOUSEAlphaFold
Function: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (By similarity). Involved in the generation of inorganic phosphate for bone mineralization (PubMed:17227223). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (PubMed:26457330, PubMed:20684022). {ECO:0000250|UniProtKB:Q8TCT1, ECO:0000269|PubMed:17227223, ECO:0000269|PubMed:20684022, ECO:0000269|PubMed:26457330}.
Subcellular Location: Extracellular vesicle {ECO:0000269|PubMed:17227223}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. {ECO:0000269|PubMed:17227223}.

Expression of "Phospho1"gene in different tissues





OCR associated with "Phospho1" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr11:95789252-95789837-34955YESIntergenic
2chr11:95791683-95792096-32610YESIntergenic
3chr11:95796342-95796824-27917YESIntergenic
4chr11:95800610-95800927-23731YESIntergenic
5chr11:95805077-95805343-19290YESIntergenic
6chr11:95805399-95805994-18803YESIntergenic
7chr11:95812209-95812720-12035YESIntergenic
8chr11:95821603-95821886-2755YESIntergenic
9chr11:95822465-95822951-1792YESIntergenic
10chr11:95823960-95824617-211YESpromoter-TSS (NM_153104)
11chr11:95825885-958260901488NOintron (NM_153104, intron 1 of 2)
12chr11:95827152-958273622757NOintron (NM_153104, intron 1 of 2)
13chr11:95827545-958277343140YESintron (NM_153104, intron 1 of 2)
14chr11:95830673-958312216447NOexon (NM_153104, exon 3 of 3)


Exposure induced DNA methylation change