ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Pkdccprotein kinase domain containing, cytoplasmicENSMUSG00000024247protein-codingPKDCC_MOUSEAlphaFold
Function: Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). May also have serine/threonine protein kinase activity (PubMed:25171405). Required for longitudinal bone growth through regulation of chondrocyte differentiation (PubMed:19097194, PubMed:23792766). May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (PubMed:19465597). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). {ECO:0000269|PubMed:19097194, ECO:0000269|PubMed:19465597, ECO:0000269|PubMed:23792766, ECO:0000269|PubMed:25171405}.
Subcellular Location: Secreted {ECO:0000269|PubMed:25171405}. Golgi apparatus {ECO:0000269|PubMed:19465597}. Note=Both secreted and present in the Golgi apparatus. {ECO:0000269|PubMed:19465597, ECO:0000269|PubMed:25171405}.

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−1−0.500.51Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−1−0.500.51Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Pkdcc"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD10152025303540
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD10152025303540
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT024681012
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT024681012
3 Weeks20 Weeks40 WeeksBloodMale
CtrlPM2.5(CHI)101520
3 Weeks20 WeeksCPMFemale
CtrlPM2.5(CHI)101520
3 Weeks20 WeeksLungMale
CtrlPM2.5(CHI)010203040
Female
010203040
HeartMale
BPA10mgBPA10ugCtrl46
Female
BPA10mgBPA10ugCtrl46
BrainMale




Tools:
Viewing a 134.7 Kb region in 920px, 1 pixel spans 146 bp
  • Sample

refGene

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gencodeM19Basic

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Ruler

chr17
qE483020K83030K83040K83050K83060K83070K83080K83090K83100K83110K83120K83130K83140K83150K83160K83170K83180K83190K83200K83210K83220K83230K83240K83250K83260K83270K83280K83290K83300K83310K83320K83330K83340K83350K83360K83370K83380K83390K83400K83410K

3 Weeks Female Liver (Ctrl)

1.00.0
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3 Weeks Male Liver (Ctrl)

1.00.0
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20 Weeks Female Blood (Ctrl)

1.00.0
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20 Weeks Male Blood (Ctrl)

1.00.0
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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Pkdcc" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr17:83148216-83148983-66683NOIntergenic
2chr17:83158629-83158950-56493YESIntergenic
3chr17:83176195-83176453-38959NOIntergenic
4chr17:83178858-83179113-36297NOIntergenic
5chr17:83182051-83182641-32937NOIntergenic
6chr17:83182918-83183194-32227NOIntergenic
7chr17:83197325-83197917-17662YESIntergenic
8chr17:83212500-83212740-2663YESIntergenic
9chr17:83213509-83213696-1680NOIntergenic
10chr17:83214125-83214482-979YESpromoter-TSS (NM_134117)
11chr17:83214668-8321599850NOpromoter-TSS (NM_134117)
12chr17:83218080-832182992907NOintron (NM_134117, intron 1 of 6)
13chr17:83219413-832197874317NOintron (NM_134117, intron 1 of 6)
14chr17:83222837-832230807676NOintron (NM_134117, intron 5 of 6)
15chr17:83224481-832249829449NO3' UTR (NM_134117, exon 7 of 7)
16chr17:83248404-8324904033439YESIntergenic
17chr17:83253090-8325340537965YESIntergenic
18chr17:83267373-8326792952368YESIntergenic
19chr17:83271576-8327179856404NOIntergenic
20chr17:83272739-8327291357543YESIntergenic
21chr17:83273688-8327400058561NOIntergenic
22chr17:83275954-8327685461121NOIntergenic
23chr17:83277744-8327800362591YESIntergenic
24chr17:83278330-8327893263348YESIntergenic


Exposure induced DNA methylation change