ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Polr2c	polymerase (RNA) II (DNA directed) polypeptide C	ENSMUSG00000031783	protein-coding	RPB3_MOUSE	AlphaFold

Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.
Subcellular Location: Nucleus {ECO:0000250}.

Expression of "Polr2c"gene in different tissues

OCR associated with "Polr2c" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr8:94857153-94858030	142	NO	exon (NM_009090, exon 1 of 9)
2	chr8:94861410-94861641	4076	YES	intron (NM_009090, intron 4 of 8)
3	chr8:94862967-94863228	5648	YES	TTS (NM_053246)
4	chr8:94864699-94865057	7428	NO	TTS (NM_009090)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Polr2c"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Polr2c" gene

Exposure induced DNA methylation change