ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Polr2f	polymerase (RNA) II (DNA directed) polypeptide F	ENSMUSG00000033020	protein-coding	RPAB2_MOUSE	AlphaFold

Function: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). {ECO:0000250}.
Subcellular Location: Nucleus {ECO:0000250}.

Expression of "Polr2f"gene in different tissues

OCR associated with "Polr2f" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr15:79140930-79141809	3	NO	promoter-TSS (NM_027231)
2	chr15:79148520-79148905	7346	YES	intron (NM_027231, intron 3 of 4)
3	chr15:79152566-79153127	11480	NO	Intergenic

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Polr2f"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Polr2f" gene

Exposure induced DNA methylation change