ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Rhbdf1	rhomboid 5 homolog 1	ENSMUSG00000020282	protein-coding	RHDF1_MOUSE	AlphaFold

Function: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q96CC6}.
Subcellular Location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q96CC6}.

Expression of "Rhbdf1"gene in different tissues

OCR associated with "Rhbdf1" gene

OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr11:32222905-32223089	-704	NO	promoter-TSS (NM_010117)
2	chr11:32221013-32222370	601	NO	intron (NM_001291818, intron 1 of 17)
3	chr11:32218586-32218879	3560	YES	intron (NM_001291818, intron 1 of 17)
4	chr11:32216937-32217170	5239	YES	intron (NM_001291818, intron 1 of 17)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Rhbdf1"gene in different tissues

Exposure induced chromatin accessibility change

OCR associated with "Rhbdf1" gene

Exposure induced DNA methylation change