ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Scd2stearoyl-Coenzyme A desaturase 2ENSMUSG00000025203protein-codingSCD2_MOUSEAlphaFold
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:16443825). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:16443825). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:16443825). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates (PubMed:16118274). Important for normal permeability barrier function of the skin in neonates (PubMed:16118274). {ECO:0000269|PubMed:16118274, ECO:0000269|PubMed:16443825}.
Subcellular Location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:16443825}; Multi-pass membrane protein {ECO:0000305|PubMed:16443825}. Microsome membrane {ECO:0000269|PubMed:16443825}.

Expression of "Scd2"gene in different tissues





OCR associated with "Scd2" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr19:44252226-44252464-41331NOIntergenic
2chr19:44254074-44254526-39376NOIntergenic
3chr19:44264320-44264505-29263NOIntergenic
4chr19:44266569-44267498-26642YESIntergenic
5chr19:44273799-44274176-19688NOIntergenic
6chr19:44276903-44277205-16622YESIntergenic
7chr19:44280815-44281036-12750NOIntergenic
8chr19:44283083-44283396-10436NOIntergenic
9chr19:44283988-44284685-9339YESIntergenic
10chr19:44292994-44293221-568YESpromoter-TSS (NM_009128)
11chr19:44293556-44294328266YES5' UTR (NM_009128, exon 1 of 6)
12chr19:44294735-442950411212YESintron (NM_009128, intron 1 of 5)
13chr19:44295814-442960882275NOintron (NM_009128, intron 2 of 5)
14chr19:44297033-442973043493YESintron (NM_009128, intron 2 of 5)


Exposure induced DNA methylation change