ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Serinc3serine incorporator 3ENSMUSG00000017707protein-codingSERC3_MOUSEAlphaFold
Function: Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm. {ECO:0000250|UniProtKB:Q13530}.
Subcellular Location: Cell membrane {ECO:0000269|PubMed:12486168}; Multi-pass membrane protein {ECO:0000269|PubMed:12486168}. Golgi apparatus membrane {ECO:0000269|PubMed:12486168}; Multi-pass membrane protein {ECO:0000269|PubMed:12486168}. Note=Localizes to the cell membrane, where it is efficiently incorporated into budding gammaretrovirus virions and impairs subsequent virion penetration of susceptible target cells (By similarity). {ECO:0000250|UniProtKB:Q86VE9}.

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Serinc3"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD200250300350400
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD200250300350400
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT1000150020002500
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT1000150020002500
3 Weeks20 Weeks40 WeeksBloodMale
CtrlPM2.5(CHI)100012001400
3 Weeks20 WeeksCPMFemale
CtrlPM2.5(CHI)100012001400
3 Weeks20 WeeksLungMale
CtrlPM2.5(CHI)0200400
Female
0200400
HeartMale
BPA10mgBPA10ugCtrl300350400
Female
BPA10mgBPA10ugCtrl300350400
BrainMale




Tools:
Viewing a 4925 bp region in 920px, 1 pixel spans 5 bp
  • Sample

refGene

Loading...

gencodeM19Basic

Loading...

Ruler

chr2
qH3163638000163639000163640000163641000163642000163643000163644000163645000163646000163647000163648000163649000163650000163651000163652000

3 Weeks Female Liver (Ctrl)

1.00.0
Loading...

3 Weeks Male Liver (Ctrl)

1.00.0
Loading...

20 Weeks Female Blood (Ctrl)

1.00.0
Loading...

20 Weeks Male Blood (Ctrl)

1.00.0
Loading...

20 Weeks Female Brain (Ctrl)

1.00.0
Loading...

20 Weeks Male Brain (Ctrl)

1.00.0
Loading...

20 Weeks Female Liver (Ctrl)

1.00.0
Loading...

20 Weeks Male Liver (Ctrl)

1.00.0
Loading...

DAR Position

Loading...

OCR Position

Loading...

OCR associated with "Serinc3" gene

Loading, please wait
OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr2:163644611-16364553570NOpromoter-TSS (NM_012032)


Exposure induced DNA methylation change