ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Sfrp1secreted frizzled-related protein 1ENSMUSG00000031548protein-codingSFRP1_MOUSEAlphaFold
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:15306229}.
Subcellular Location: Secreted {ECO:0000250}. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding (By similarity). {ECO:0000250}.

Expression of "Sfrp1"gene in different tissues





OCR associated with "Sfrp1" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr8:23411287-23411664-26YESpromoter-TSS (NM_013834)
2chr8:23419366-234198188090NOintron (NM_013834, intron 2 of 2)
3chr8:23425244-2342562813934YESintron (NM_013834, intron 2 of 2)
4chr8:23428751-2342902217385NOintron (NM_013834, intron 2 of 2)
5chr8:23435374-2343615524263NOintron (NM_013834, intron 2 of 2)
6chr8:23436635-2343688125256NOintron (NM_013834, intron 2 of 2)
7chr8:23470211-2347062658917NOIntergenic
8chr8:23476015-2347636864690NOIntergenic
9chr8:23477513-2347814366326NOIntergenic
10chr8:23507657-2350815996406NOIntergenic


Exposure induced DNA methylation change