ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Sh2b3SH2B adaptor protein 3ENSMUSG00000042594protein-codingSH2B3_MOUSEAlphaFold
Function: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.
Subcellular Location:

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.6−0.4−0.200.20.40.6Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.6−0.4−0.200.20.40.6Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Sh2b3"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD10152025
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD10152025
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT150200250300350
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT150200250300350
3 Weeks20 Weeks40 WeeksBloodMale





Tools:
Viewing a 18.4 Kb region in 920px, 1 pixel spans 20 bp
  • Sample

refGene

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gencodeM19Basic

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Ruler

chr5
qF121810K121820K121830K121840K121850K121860K

3 Weeks Female Liver (Ctrl)

1.00.0
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3 Weeks Male Liver (Ctrl)

1.00.0
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20 Weeks Female Blood (Ctrl)

1.00.0
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20 Weeks Male Blood (Ctrl)

1.00.0
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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Sh2b3" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr5:121842692-121843129-6052NOIntergenic
2chr5:121842345-121842526-5577NOIntergenic
3chr5:121838434-121839365-2041NOIntergenic
4chr5:121836323-121837524-65NOpromoter-TSS (NM_008507)
5chr5:121835372-121835705565YESintron (NM_001306127, intron 1 of 8)
6chr5:121833847-1218341862087YESintron (NM_001306127, intron 1 of 8)
7chr5:121831277-1218315634684NOintron (NM_001306128, intron 1 of 7)
8chr5:121828780-1218292777075YESexon (NM_008507, exon 2 of 8)



Exposure induced DNA methylation change