ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Stub1STIP1 homology and U-Box containing protein 1ENSMUSG00000039615protein-codingCHIP_MOUSEAlphaFold
Function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:11435423, PubMed:21855799). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:11435423, PubMed:21855799). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (By similarity). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (By similarity). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (By similarity). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (By similarity). Mediates polyubiquitination of CYP3A4 (By similarity). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (By similarity). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (PubMed:24043303). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (By similarity). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (By similarity). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (By similarity). {ECO:0000250|UniProtKB:Q9UNE7, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:21855799, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24043303}.
Subcellular Location: Cytoplasm {ECO:0000269|PubMed:11435423}. Nucleus {ECO:0000250|UniProtKB:Q9UNE7}. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000250|UniProtKB:Q9UNE7}.

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Stub1"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD30405060708090
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD30405060708090
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT102030405060
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT102030405060
3 Weeks20 Weeks40 WeeksBloodMale





Tools:
Viewing a 5796 bp region in 920px, 1 pixel spans 6 bp
  • Sample

refGene

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gencodeM19Basic

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Ruler

chr17
qA3.3258250002582600025827000258280002582900025830000258310002583200025833000258340002583500025836000258370002583800025839000258400002584100025842000

3 Weeks Female Liver (Ctrl)

1.00.0
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3 Weeks Male Liver (Ctrl)

1.00.0
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20 Weeks Female Blood (Ctrl)

1.00.0
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20 Weeks Male Blood (Ctrl)

1.00.0
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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Stub1" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr17:25833837-25834354-735NOpromoter-TSS (NM_019719)
2chr17:25832559-25833615274NO5' UTR (NM_019719, exon 1 of 7)



Exposure induced DNA methylation change