ToxiTaRGET

ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene Symbol	Gene Name	Ensemble ID	Status	UniProt ID	Structure Visualization
Tctn2	tectonic family member 2	ENSMUSG00000118662	protein-coding	TECT2_MOUSE	AlphaFold

Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction. {ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:21725307, ECO:0000269|PubMed:22179047}.
Subcellular Location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:21725307}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.

Expression of "Tctn2"gene in different tissues

Tools:

Viewing a 16.8 Kb region in 920px, 1 pixel spans 18 bp

Sample

refGene

gencodeM19Basic

Ruler

chr5

3 Weeks Female Liver (Ctrl)

3 Weeks Male Liver (Ctrl)

20 Weeks Female Blood (Ctrl)

20 Weeks Male Blood (Ctrl)

20 Weeks Female Brain (Ctrl)

20 Weeks Male Brain (Ctrl)

20 Weeks Female Liver (Ctrl)

20 Weeks Male Liver (Ctrl)

DAR Position

OCR Position

OCR associated with "Tctn2" gene

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OCR	Position	Distance to TSS	Differential accessibility	Annotation
1	chr5:124592784-124593161	-5776	YES	intron (NM_181410, intron 9 of 12)
2	chr5:124598509-124599077	44	YES	promoter-TSS (NM_026486)
3	chr5:124604348-124605581	6216	NO	intron (NM_026486, intron 5 of 17)

Gene information

Exposure induced expression change

Gene expression across exposure

Expression of "Tctn2"gene in different tissues

Exposure induced chromatin accessibility change

Current terms

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OCR associated with "Tctn2" gene

Exposure induced DNA methylation change