ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Tfectranscription factor ECENSMUSG00000029553protein-codingTFEC_MOUSEAlphaFold
Function: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11818452}.
Subcellular Location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.

Expression of "Tfec"gene in different tissues





OCR associated with "Tfec" gene

OCRPositionDistance to TSSDifferential accessibilityAnnotation
1chr6:16965749-16965950-67409YESIntergenic
2chr6:16963986-16964267-65686NOIntergenic
3chr6:16898337-16898614-35YESpromoter-TSS (NM_031198)
4chr6:16896520-168967871787YESintron (NM_031198, intron 1 of 6)
5chr6:16891720-168922566453YESintron (NM_031198, intron 1 of 6)
6chr6:16870079-1687048028161YESintron (NM_031198, intron 1 of 6)
7chr6:16822064-1682231176253YESIntergenic
8chr6:16797520-16798010100676NOIntergenic
9chr6:16701925-16702191196383YESIntergenic
10chr6:16700872-16701232197389YESIntergenic
11chr6:16697246-16697674200981YESIntergenic
12chr6:16668101-16668302230239NOIntergenic
13chr6:16552339-16552672345935NOIntergenic
14chr6:16551004-16551588347145YESIntergenic
15chr6:16550542-16550794347773YESIntergenic
16chr6:16524061-16524517374152NOIntergenic
17chr6:16503870-16504167394422NOIntergenic
18chr6:16360002-16360344538268YESIntergenic
19chr6:16316355-16316772581877NOIntergenic


Exposure induced DNA methylation change