ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Trafd1TRAF type zinc finger domain containing 1ENSMUSG00000042726protein-codingTRAD1_MOUSEAlphaFold
Function: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. {ECO:0000269|PubMed:16221674, ECO:0000269|PubMed:18849341}.
Subcellular Location:

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Trafd1"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD303540455055
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD303540455055
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT406080100120140160
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT406080100120140160
3 Weeks20 Weeks40 WeeksBloodMale





Tools:
Viewing a 79.3 Kb region in 920px, 1 pixel spans 86 bp
  • Sample

refGene

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gencodeM19Basic

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Ruler

chr5
qF121240K121250K121260K121270K121280K121290K121300K121310K121320K121330K121340K121350K121360K121370K121380K121390K121400K121410K121420K121430K121440K121450K121460K121470K

3 Weeks Female Liver (Ctrl)

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3 Weeks Male Liver (Ctrl)

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20 Weeks Female Blood (Ctrl)

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20 Weeks Male Blood (Ctrl)

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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Trafd1" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr5:121389010-121389516-3648NOIntergenic
2chr5:121387139-121387560-1735NOIntergenic
3chr5:121384921-121385957176NOintron (NM_172275, intron 1 of 11)
4chr5:121383974-1213841321562NOexon (NM_001163470, exon 2 of 12)
5chr5:121377787-1213782187612NOintron (NM_172275, intron 5 of 11)
6chr5:121377069-1213772688446YESintron (NM_172275, intron 6 of 11)
7chr5:121368606-12136897616824NOTTS (NM_181421)
8chr5:121367327-12136766918117NO3' UTR (NM_181421, exon 76 of 76)
9chr5:121341241-12134154444222YESintron (NM_181421, intron 55 of 75)
10chr5:121340771-12134097944740NOintron (NM_181421, intron 55 of 75)
11chr5:121336744-12133708048703NOintron (NM_181421, intron 54 of 75)
12chr5:121335527-12133579549954YESintron (NM_181421, intron 53 of 75)
13chr5:121333838-12133463851377NOintron (NM_181421, intron 52 of 75)
14chr5:121330249-12133076755107YESintron (NM_181421, intron 49 of 75)
15chr5:121329057-12132980956182NOintron (NM_181421, intron 48 of 75)
16chr5:121314206-12131444971287NOintron (NM_181421, intron 35 of 75)



Exposure induced DNA methylation change