Gene information
Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:15603741, PubMed:17012030, PubMed:28167757). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (By similarity). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (By similarity). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (PubMed:15603741). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (PubMed:15603741, PubMed:17012030). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (PubMed:18596047). Could also palmitoylate FYN as shown in vitro (By similarity). {ECO:0000250|UniProtKB:F1QXD3, ECO:0000250|UniProtKB:Q96MV8, ECO:0000269|PubMed:15603741, ECO:0000269|PubMed:17012030, ECO:0000269|PubMed:18596047, ECO:0000269|PubMed:28167757, ECO:0000305|PubMed:28167757}. | Subcellular Location: Golgi apparatus membrane {ECO:0000269|PubMed:18596047}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F1QXD3}. Postsynaptic density {ECO:0000250|UniProtKB:Q2TGJ4}. |
Expression of "Zdhhc15"gene in different tissues
OCR associated with "Zdhhc15" gene
