ToxiTaRGET Database of Toxicant Exposures and Responses

Gene information

Gene SymbolGene NameEnsemble IDStatusUniProt IDStructure Visualization
Zfp709zinc finger protein 709ENSMUSG00000056019protein-codingQ8C0I0_MOUSEAlphaFold
Function: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. {ECO:0000256|PIRNR:PIRNR013212}.
Subcellular Location: Nucleus {ECO:0000256|PIRNR:PIRNR013212}. Cytoplasm {ECO:0000256|PIRNR:PIRNR013212}.

BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksMale
BloodBrainHeartLiverLungAsBPA10mgBPA10ugDEHPPM2.5(CHI)PM2.5(JHK)PbTBTTCDDBloodBrainHeartLiverLungBloodLiver
−0.500.5Fold Change3 Weeks20 Weeks40 WeeksFemale

Expression of "Zfp709"gene in different tissues
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD246810
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TBTTCDD246810
3 Weeks20 Weeks40 WeeksLiverMale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT51015
3 Weeks20 Weeks40 WeeksCPMFemale
AsBPA10mgBPA10ugCtrlDEHPPbPM2.5(CHI)PM2.5(JHK)TCDDTBT51015
3 Weeks20 Weeks40 WeeksBloodMale
CtrlPM2.5(CHI)81012
3 Weeks20 WeeksCPMFemale
CtrlPM2.5(CHI)81012
3 Weeks20 WeeksLungMale
CtrlPM2.5(CHI)02468
Female
02468
HeartMale
BPA10mgBPA10ugCtrl10121416
Female
BPA10mgBPA10ugCtrl10121416
BrainMale




Tools:
Viewing a 81.6 Kb region in 920px, 1 pixel spans 89 bp
  • Sample

refGene

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gencodeM19Basic

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Ruler

chr8
qB3.371730K71740K71750K71760K71770K71780K71790K71800K71810K71820K71830K71840K71850K71860K71870K71880K71890K71900K71910K71920K71930K71940K71950K71960K

3 Weeks Female Liver (Ctrl)

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3 Weeks Male Liver (Ctrl)

1.00.0
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20 Weeks Female Blood (Ctrl)

1.00.0
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20 Weeks Male Blood (Ctrl)

1.00.0
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20 Weeks Female Brain (Ctrl)

1.00.0
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20 Weeks Male Brain (Ctrl)

1.00.0
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20 Weeks Female Liver (Ctrl)

1.00.0
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20 Weeks Male Liver (Ctrl)

1.00.0
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DAR Position

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OCR Position

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OCR associated with "Zfp709" gene

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OCR
Position
Distance to TSS
Differential accessibility
Annotation
1chr8:71804792-71805222-77061YESIntergenic
2chr8:71812359-71812670-69553NOIntergenic
3chr8:71819784-71820028-62162YESIntergenic
4chr8:71820060-71820370-61853NOIntergenic
5chr8:71823766-71824176-58097NOIntergenic
6chr8:71825678-71825958-56250YESIntergenic
7chr8:71826685-71826978-55236YESIntergenic
8chr8:71838179-71838462-43747NOIntergenic
9chr8:71841262-71841594-40640NOIntergenic
10chr8:71846763-71847021-35176NOIntergenic
11chr8:71849983-71850255-31949YESIntergenic
12chr8:71853326-71853694-28558NOIntergenic
13chr8:71857439-71857718-24489YESIntergenic
14chr8:71858370-71858636-23565YESIntergenic
15chr8:71859335-71859560-22620YESIntergenic
16chr8:71881588-71882404-72NOpromoter-TSS (NM_145624)


Exposure induced DNA methylation change