Introduction: Bisphenol A is also known as "BPA". It is a synthetic organic compound used in the production of plastics, specifically in the manufacturing of polycarbonate plastics and epoxy resins. It has been widely used in a variety of consumer products, such as food and beverage containers, dental sealants, and the lining of cans.
Environmental Effects: BPA is a well-known environmental pollutant. It can leach from plastic products into the environment, potentially contaminating water sources and aquatic ecosystems. The compound's persistence and widespread use have raised concerns about its impact on the environment. BPA has been found to disrupt endocrine functions in some wildlife species, affecting their reproductive systems.
Associated Diseases: BPA is considered an endocrine-disrupting chemical, and there is growing concern about its potential health effects on humans. Research suggests that BPA exposure may be associated with various health issues, including hormonal imbalances, obesity, diabetes, cardiovascular diseases, and reproductive disorders. It can mimic the action of the hormone estrogen, potentially leading to hormone-related problems.
Additional Resources
Centers for Disease Control and Prevention: Bisphenol A (BPA) FactsheetFood and Drug Administration: Bisphenol A (BPA): Use in Food Contact Application
National Institutes of Health: Bisphenol A Fact Sheet
Table1. Number of differentially expressed gene under BPA10mg exposure.
| Age | Tissues | Sex | Up-regulated | Down-regulated |
|---|---|---|---|---|
| 3 Weeks | Blood | 808 | 337 | |
| 526 | 1127 | |||
| Liver | 22 | 8 | ||
| 2 | 8 | |||
| 20 Weeks | Blood | 1425 | 1680 | |
| 481 | 242 | |||
| Brain | 905 | 669 | ||
| 1 | 0 | |||
| Liver | 79 | 15 | ||
| 156 | 100 | |||
| 40 Weeks | Liver | 269 | 172 | |
| 461 | 180 |
Table2. Number of differentially accessible regions under BPA10mg exposure.
| Age | Tissues | Sex | DAR |
|---|---|---|---|
| 3 Weeks | Liver | 3594 | |
| 4267 | |||
| 20 Weeks | Blood | 4077 | |
| 2454 | |||
| Brain | 17137 | ||
| 59 | |||
| Liver | 5627 | ||
| 10444 |
Table3. Number of differentially methylated regions under BPA10mg exposure.
| Age | Tissues | Sex | Hypomethylated | Hypermethylated |
|---|---|---|---|---|
| 20 Weeks | Blood | 46478 | 4350 | |
| 4132 | 2024 | |||
| Cortex | 357 | 965 | ||
| 177 | 219 | |||
| Liver | 1324 | 263 | ||
| 1284 | 1475 |